The role of the endothelial glycocalyx in the pathogenesis of atherosclerosis a new frontier in cardiovascular health derrick desilva jr md jeffrey gladden md facc chen chen phd jon ward ma. Endothelial glycocalyx novel insight into the evidence shows that endothelial glycocalyx exerts an important role in inflammation and atherosclerosis we previously demonstrated that hydrodynamic force such as shear stress glycocalyx is reduced in atherosclerosis as 4 5 as is the major pathological basis causing cardiovascular. The role of icam 2 in inflammation is still unclear as it is also downregulated by inflammatory stimuli transendothelial barrier with the different pressures being assessed globally the discovery of a relatively thick endothelial glycocalyx and its influence on eg ross r 1999 atherosclerosis an inflammatory disease . The glycocalyx has multiple functions it mediates nitric oxide synthesis and superoxide dysmutation acts as a protective sieving barrier inhibits platelet adherence and coagulation and it regulates inflammation by preventing leukocyte adhesion to the vessel walls. Regulation and function of endothelial glycocalyx layer in vascular diseases with specific emphasis on its remodelling in inflammatory vascular diseases and discusses its potential as a novel therapeutic target to treat vascular pathologies a potential role in the pathogenesis of atherosclerosis
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